Almost certainly not. The game was designed for Android 4.4 KitKat. The software and architecture are too different, and it will likely crash or fail to launch entirely.
Check out these gameplay demonstrations and tutorials for running DMC4: Refrain on modern Android devices: Devil May Cry 4 Refrain (iOS) on Android Device in 2025 9K views · 9 months ago YouTube · Save & Game Collections install download devil may cry 4 refrain android
If it does not already exist, create a new folder named com.capcom.dmc4refrain . Almost certainly not
This contains the large graphics, audio, and asset files. and asset files.