Ensure your version of DMC3 SE (Steam HD Collection vs. original 2006 PC port) matches the trainer build. Using an outdated trainer on a newer game patch can cause immediate desktop crashes.
Because trainers manipulate memory, online leaderboards (if you care about them) will likely flag your run. Do not stream with the trainer overlay visible if you are trying to set a world record. Use it for fun, not for clout. devil may cry 3 special edition trainer fling