A handful of PS2 games require specific "Modes" turned on within Open PS2 Loader (OPL) to function properly over USB.
Under "Media", ensure or DVD is checked depending on the game type. Click the Create button. Usbutil 3.0 Ps2
Download a trusted version of USBUtil (such as v2.2 Rev or a community stable build) and extract the ZIP file. Right-click USBUtil.exe and select . A handful of PS2 games require specific "Modes"