If you need a fully-featured desktop CAD application without the premium price tag, FreeCAD is an excellent open-source alternative.
If your goal is to use AutoCAD without installing heavy software: Autocad Portable 2012 64
This official process was not designed to be "portable." The installers were several gigabytes in size and required significant system integration. Therefore, any "portable" version is a hacked-down, compromised piece of software. If you need a fully-featured desktop CAD application