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Unexplained aggression in an otherwise gentle animal is a classic red flag for localized or systemic pain. Chronic conditions such as osteoarthritis, dental disease, or intervertebral disc disease (IVDD) can make an animal hyper-reactive to touch or approach. When a veterinarian evaluates a behavioral complaint through a medical lens, they can diagnose and treat the source of pain, which often resolves the unwanted behavior entirely. Endocrine Disorders

. It uses tools like X-rays and blood tests to diagnose physical ailments. Animal Behavior (Ethology) Unexplained aggression in an otherwise gentle animal is

| Behavioral Sign | Possible Medical Cause | | :--- | :--- | | Sudden aggression (dog/cat) | Pain (dental disease, arthritis), brain tumor, hypothyroidism, rabies | | House soiling (cat) | Urinary tract infection, chronic kidney disease, diabetes, hyperthyroidism | | Compulsive circling (dog) | Forebrain lesion, hepatic encephalopathy | | Night waking/vocalizing (senior pet) | Cognitive dysfunction syndrome (canine/feline dementia) | | Pica (eating non-food items) | Anemia, exocrine pancreatic insufficiency, dietary deficiency | Endocrine Disorders