Which are you running (Windows, Mac, or Linux)? What type of controller do you plan to use?
Drag and drop your standard Ninja Gaiden Black ISO onto the extract-xiso.exe executable. ninja+gaiden+black+xiso+download+install
Xemu requires specific system files extracted from an original Xbox console to boot. You will need to gather these files before loading your game. Required Files Which are you running (Windows, Mac, or Linux)
Downloading copyrighted game files is generally against terms of service; you should dump your own disc if possible. However, the process for preparing the file is consistent: Which are you running (Windows