Asin is one of the few actresses to have a No. 1 film in Tamil, Telugu, and Hindi in the same year (2008: Dasavathaaram in Tamil, Pokkiri in Telugu, Ghajini in Hindi). Entertainment portals still list her in "GOAT (Greatest of All Time) cross-over actresses."

Asin leads an elegant, private lifestyle divided between New Delhi and international destinations.

She made history in Bollywood with the 2008 remake of Ghajini opposite Aamir Khan, which became the first film to cross the ₹100-crore mark domestically.